Zovirax Duo Aciclovir, Hydrocortisonum cream tube 2g

Zovirax Duo Aciclovir, Hydrocortisonum cream tube 2g

Product Code: 9124
Availability: In Stock

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active ingredients: 1 g of cream contains acyclovir 50 mg, hydrocortisone 10 mg

excipients: propylene glycol, white soft paraffin, mineral oil, cetostearyl alcohol, methyl ethyl ketone, poloxamer, sodium lauryl sulfate, citric acid monohydrate, sodium hydroxide, hydrochloric acid concentrated, and purified water.


Dosage form


Basic physical and chemical properties: homogeneous white cream in an aluminum tube.


drug description

Antiviral agents. Code ATC D06B B03.


Pharmacological properties


Acyclovir is a antiviral drug that has a high activity in vitro against herpes simplex virus types I and II. The toxic effect against cells of the host organism is minimal. Getting into cells infected with the herpes virus, acyclovir phosphorylated to form an active compound-acyclovir triphosphate. The first stage of this process depends on the presence of thymidine kinase virus. Acyclovir triphosphate acts as an inhibitor and substrate for viral DNA polymerase, preventing further viral DNA synthesis without affecting normal cellular processes.

Hydrocortisone is a weak GCS that detects a number of immunomodulatory

effects. When applied topically, its primary role is to control various inflammatory skin lesions.

cream with acyclovir and hydrocortisone, which combines the antiviral effect of acyclovir and the anti-inflammatory effect of hydrocortisone, reduces the progression of herpetic bubbles to the formation of ulcers, as well as reduces the healing time of lesions.

the Exact mechanism of this is insufficiently studied, but it is believed that it is mediated by virus clearance and a decrease in the local inflammatory response on the lips, which leads to a decrease in the signs and symptoms of recurrent herpes.

The Pharmacokinetics.

No clinical studies of pharmacokinetics have not been conducted for acyclovir cream

and hydrocortisone.


Treatment of early signs and symptoms of recurrent herpes on the lips (herpes vesicles) to reduce the progression of episodes of herpes vesicles to the formation of ulcers and reduce the healing time of lesions in immunocompetent adults and children over 12 years.


Hypersensitivity to acyclovir, valacyclovir, propylene glycol or other components of the cream.

use in skin lesions caused by any virus other than herpes simplex or for the treatment of fungal, bacterial or parasitic skin infections.

Special safety precautions

Cream should be used only for the treatment of herpes on the lips and face. It is not recommended to apply the cream on the mucous membranes of the mouth, eyes and apply it to treat genital herpes. You should avoid accidentally getting the cream in your eyes.

Patients with particularly severe and recurrent manifestations of herpes labialis require medical advice. Patients with herpes should be warned against contact transmission of the virus to other people, especially in the presence of open lesions (in particular, you need to wash your hands before and after using the cream). It is not recommended for people with immunodeficiency. Such patients need to consult a doctor for treatment of any infection.


Interaction with other medicinal products and other forms of interaction

Interactions have been identified.

application Features

use during pregnancy or lactation. Pregnant and breastfeeding, the drug is recommended only when the benefits, according to the doctor, exceed the risk.

Ability to influence the reaction rate when driving motor transport or operating other mechanisms. No data.

Method of application and doses

the Preparation is intended for external use.

Adults and children over 12 years old apply the cream 5 times a day at approximately 4-hour intervals, except at night. Treatment should begin as early as possible, preferably immediately after the first signs or symptoms.

Each time, a sufficient amount of cream should be applied to cover the affected area, including the outer edges of the lesion, if any.

Treatment lasts for at least 5 days. If healing has not occurred, you can continue treatment for up to 10 days. If the symptoms do not disappear after 10 days of treatment, the patient should consult a doctor. Wash hands before and after using the cream and avoid excessive friction or touching the affected areas with a towel to prevent exacerbation or transmission of infection.


data on the safety of the drug in children under the age of 12 years is not enough, so it is recommended to use in children aged 12 years.


oral or local application of the whole tube of cream adverse effects were not detected because of the minimal systemic effects. In the event of suspected overdose you must seek medical help.

Side effects

the part of the skin and subcutaneous tissue:

Often (? 1/100,<1/10) drying and flaking of the skin.

Rare (? 1/1 000,<1/100): transient acute or burning pain, tingling (after treatment), itching.

Liquid (? 1/10 000,<1/1 000): erythema, pigmentation changes. When conducting safety studies for the skin, contact dermatitis was noted after applying the cream under the bandage. When conducting tests on the sensitivity of the reactive substance were hydrocortisone or a component of a cream base. There were reactions at the site of application, including manifestations and symptoms of inflammation.

from the immune system:

Very rarely (<1/1 000): reactions of immediate hypersensitivity, including angioedema.

in tests on the sensitivity of these cases were associated with the components of the cream base and not with acyclovir. There are isolated reports of immediate hypersensitivity reactions, including angioedema, due to local use of acyclovir.


shelf Life

2 years old.

storage Conditions

Store at temperature below 25 C, out of reach of children. Not freeze.



to 2 g of cream in a tube. 1 tube in a cardboard box.


Category vacation

over the counter.



Glaxo operations UK limited, United Kingdom/Glaxo Operations UK Ltd, United Kingdom.

location of the manufacturer and address of the place of business

Address: Harmer road, Barnard castle, Durham, DL12 8DT, UK.

Harmire Road, Barnard Castle, Durham, DL12 8DT, United Kingdom.


Asimelec capsules 40 g No. 14 have antiulcer effect. The composition of the drug include esomeprazole, which begins to be active after 40-45 minutes after taking the medicine. 


the Drug is used for:

  • Esophagitis.
  • The
  • a stomach Ulcer.

the Drug is also used in complex General therapy during the treatment of ulcers of the gastrointestinal tract, duodenal ulcers, GERD. In addition, the capsules are assigned as the current preventive means for patients who have recovered from esophagitis.

when taking the drug in the stomach, the activity of acid production (hydrochloric) decreases significantly as a result of complete inhibition of the proton layer in the parietal cells of the gastrointestinal tract.

Dosage and method of acquisition

Means use inside the food. The recommended dosage for symptomatic therapy of GERD is 20 mg of the drug (half a tablet) per day. The average course of treatment should be 4 weeks. In the treatment of esophagitis (erosive) you should drink 40 mg of the drug (1 tablet) per day, while with the duodenal ulcer – taking 20 mg. Before the use of Somelocal consult a doctor.

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