active substance:1 ml of the hydrolysate brain of cattle and pigs containing amino acids and peptides (in terms of dry substance) total - 57-87 mg/ml. the Total content of amino acids 27-42 mg/ml, including every amino acids (in mg/ml) L-lysine - 0,4-5,5; L-Histidine - 0,3-4,5; L-arginine - 0,8-5,4; L-aspartic acid - 1,0-3,5; L-threonine - 0,7-4,2; L-serine - 0,4-3,5; L-glutamic acid - 3,0-6,5; L-alanine - 0,8-5,2; L-Proline 0,4-4,2; Glycine - 0,7-2,1; L-valine - 1,3-4,1; L-Methionine - 0,4-2,0; L-leucine - 2,0-6,0; L-phenylalanine-0,4-2,0; L-isoleucine-0,8-3,6; L-tyrosine-0,2-0,7;
Solution for injection.
Psychostimulant and nootropic drugs. ATC code N06B X.The
In the complex treatment of progressive of cognitive and intellectual-mnestic functions with:The
ischemic stroke (acute and recovery periods) The
hypersensitivity to the drug, acute renal failure, epilepsy, pregnancy and breast-feeding.
dosage and administration.
the Drug should be used only parenterally in the form of intramuscular injections (1-5 ml) or intravenous drip infusions (10-50 ml). The dose and duration of treatment depend on the nature, severity of the disease, as well as the age of the patient.
the Standard duration of treatment is 4 weeks (minimum 5 injections per week, daily if possible).
Acute ischemic stroke, acute period of craniocerebral trauma, the postoperative period after neurosurgical operationsintravenous drip daily, in a daily adult dose 10-50 ml (100-250 ml saline) for 60-90 min Duration: 10-25 days.
Recovery period of stroke, the residual period of traumatic brain damage- adults 5-10 ml/day for 20-30 days.
Psychoorganic syndrome and depression, neurocirculatory dystonia- in the form of intravenous infusion dose adults 5-10 ml for 20-25 and 10-15 days, respectively.
Dementia, vascular and mixed Genesis, Alzheimer's disease- recommended doses for adults are 20-30 ml 100-200 ml of saline. The course of treatment - 20 injections.
by the immune system
Single (<1/10000) - hypersensitivity or allergic reactions, anaphylactic shock, angioedema, fever, chills.
Rare (>1/10000 -<1/1000) - loss of appetite.
Rare (>1/10000 -<1/1000) - in rare cases, the therapeutic effect was accompanied with agitation (aggression, confusion, insomnia), depression, apathy.
from nervous system
Rare (>1/10000 -<1/1000) - with the rapid introduction of possible dizziness, tremor, headache.
Single seizures (<1/10000) - large epileptic seizures (grand mal).
on the cardiovascular side
Rare (>1/10000 -<1/1000) - hypertension, hypotension.
Single (<1/10000) - with the rapid introduction of possible palpitations and arrhythmia, heart pain.
from the respiratory system
Rare (>1/10000 -<1/1000) - hyperventilation, shortness of breath, chest pain.
from the gastrointestinal tract
Single (<1/10000) - dyspepsia, diarrhea, constipation, nausea, vomiting.
on the part of the skin and subcutaneous tissue
Rare (>1/10000 -<1/1000) - with the rapid introduction of possible sensation of heat, sweating, itching, and possible maculopapular rash, urticaria, redness of the skin.
General Reactions and local reactions
Rare (>1/10000 -<1/1000) - fatigue, flu-like symptoms (runny nose, cough).
Single (<1/10000) - local inflammatory reaction, erythema and burning at the injection site, itching at the injection site.
Single (<1/10000) - pain in the neck, limbs, lower back.
so far, cases of overdose of Seregin was not reported.
Use during pregnancy or breast-feeding.
Studies in animals showed reproductive toxicity Zeregin. However, people such tests were not conducted. The drug is contraindicated in pregnancy and breast-feeding.The
there is no Experience of the drug in children, so it is recommended to use it for patients of this age category.
features of the application.
Special care should be taken when assigning Zeregin patients with allergic diathesis.
Ability to influence the reaction rate when driving motor transport or operating other mechanisms.
when using the drug, dizziness is possible, you should refrain from driving and working with mechanisms that require increased attention and rapid mental and motor reactions.
Interaction with other medicinal products and other forms of interaction.
Taking into account the pharmacological profile of the drug, special attention should be paid to possible additive effects in the case of simultaneous use with antidepressants or MAO inhibitors. In such cases, it is recommended to reduce the dose of antidepressants.
Zeregin should not be mixed with balanced amino acid solutions in an infusion bottle.
the product contains low molecular weight biologically active neuropeptides, which pass through the blood-brain barrier and go directly to nerve cells. Organo has a multimodal effect on the brain, manifested in the ability of the drug to metabolic regulation, functional neuromodulation and neurotrophic activity. It has neuroprotective effect.
Metabolic regulation. Increases the efficiency of aerobic energy metabolism of the brain, improves intracellular protein synthesis in the brain.
Neuroprotective action. The drug protects neurons from the harmful effects of lactic acidosis, prevents the formation of free radicals and reduces the concentration of products of lipid peroxidation in the model of ischemia - reperfusion, increases survival and prevents the death of neurons under conditions of hypoxia and ischemia, reduces the damaging neurotoxic effects of excitatory amino acids (glutamate).
Neurotrophic activity. Due to neurotrophic activity (similar to the action of the natural nerve growth factor), the drug can significantly slow down, and in some cases stop the progression of neurodegenerative processes in the brain.
Functional neuromodulations. The drug has a positive effect in disorders of cognitive functions, improves concentration, memory processes and recovery of information associated with short-term memory, activates the process of mental activity, improves mood, promotes the formation of positive emotions, showing thus modulyarnye influence on behavior.
has Not been studied.
transparent yellowish liquid.The
Zeregin incompatible with solutions that change the pH of the drug (5,0-8,0) and with solutions containing lipids.The
Store in its original packaging at a temperature not exceeding 25 ° C.The
1 ml or 5 ml ampoules each. For 5 ampoules in a blister. 2 blister ampoules of 1 ml in a pack; 1 or 2 blister ampoules of 5 ml in a pack.The
According to the recipe.The
30 fabritsiusa street, Minsk, 220007, Republic of Belarus.
Zeregin is a neuroprotective drug used for the regulation of cerebral blood flow. The main component of treatment is the hydrolyzate of the brain of pigs and cattle.
the drug is Used as protection of brain neurons from the negative effects of the process of lactic acidosis. Applied to slow down, sometimes stop, neurodegenerative processes of the brain, improve concentration, activation of memory processes, mental activity.
Side effects: aggression, sleep disturbance, nausea, vomiting, diarrhea, redness of the skin, itching, dizziness, arrhythmia, allergic reactions. Contraindications: epilepsy, kidney disease, pregnancy. Take only as directed by a healthcare practitioner.
is Used in the form of intramuscular injections of one to five ml of intravenous infusions of from ten to fifty ml. Dosage, period, mode of taking medications depend on the severity of the disease and the patient's age.