AQUADETRIM VIT D3 Colecalciferol solution 15000IU/ml fl 10ml

AQUADETRIM VIT D3 Colecalciferol solution 15000IU/ml fl 10ml

Product Code: 4700
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Composition

active substance:cholecalciferol;

1 ml (approximately 30 drops) solution contains colecalciferol 15,000 IU (1 drop contains approximately 500 IU of vitamin d3)

excipients:macrogolglycerol ricinoleate; sucrose; sodium phosphate dodecahydrate; citric acid monohydrate, anise flavor; benzyl alcohol; purified water.

The

Dosage form

aqueous solution for oral administration.

basic physical and chemical properties:colorless transparent liquid with anise smell and taste. Opalescence is allowed in the preparation.

The

drug description

Vitamins. Vitamin D and its analogues.

ATX Code A11C S05.

The

Pharmacological properties

Pharmacodynamics.

vitamin d3Is an active antirachitic factor. The most important function of vitamin D is to regulate the metabolism of calcium and phosphates, promotes proper mineralization and growth of the skeleton.

vitamin d3Is a natural form of vitamin d that is produced in animals and humans. Compared with vitamin D2is characterized by activity, higher by 25%.

it is necessary for the functioning of the parathyroid glands, intestines, kidneys and bone system. Plays an essential role in the absorption of calcium and phosphates from the intestine, in the transport of mineral salts and in the process of calcification of bones, regulates the excretion of calcium and phosphates by the kidneys. The concentration of calcium ions affects a number of important biochemical processes that cause support muscle tone skeletal muscles involved in nerve excitation and affect blood clotting. Vitamin d3is also involved in the functioning of the immune system, affects the production of lymphokines.

Lack of vitamin d3in food, weakening of its absorption, calcium deficiency, as well as lack of exposure to sunlight during rapid growth of the child lead to rickets, and adults - to osteomalacia, pregnant women - before the symptoms of tetanus and uneducation of tooth enamel in infants.

women in menopause who often suffer from osteoporosis should increase the dose of vitamin d3due to hormonal disorders .

Pharmacokinetics.

Suction

.

aqueous solution of vitamin d3is better absorbed than oil. In premature infants, there is insufficient education and the flow of bile into the intestine, which violates the absorption of vitamins in the form of oil solutions.

after oral administration, cholecalciferol is absorbed in the small intestine.

Distribution.crosses the placental barrier and in breast milk.

Metabolism.is Metabolized in the liver and kidneys, turning into an active metabolite - calcitriol, which connects to the carrier protein and is transported to the target organs (intestines, bones, kidneys). The half-life in the blood is several days and may last in case of kidney disease.

Output.is Excreted in the urine and feces.

Vitamin d3is involved in the regulation of phosphorus and calcium metabolism in the body 6:00 after taking the drug.

after taking vitamin d3after 48 hours there has been a significant increase in serum cholecalciferol levels.

Reading

The
    The
  • Prevention of rickets;
  • Prevention of vitamin d deficiency3in high-risk groups, do not have suction disorders;
  • prevention of rickets in premature infants;
  • prevention of vitamin d deficiency3malabsorption;
  • treatment of rickets and osteomalacia;
  • The
  • supportive treatment of osteoporosis
  • The
  • treatment for hypoparathyroidism.

Contra

hypersensitivity to the components of the drug, hypercalcemia and/or hypercalciuria, hypervitaminosis D, sarcoidosis, renal failure, nephrolithiasis, tuberculosis. Pseudohypoparathyroidism (the need for vitamin D may be lower than during normal vitamin sensitivity). Taking vitamin D can lead to an overdose risk. In such situations, vitamin D should be used in other dosage forms to make it easier to control the concentration. The drug is contraindicated to patients with rare hereditary fructose intolerance, glucose-galactose malabsorption or sucrose-solmonese failure.

The

Interaction with other medicinal products and other forms of interaction

Antiepileptic agents such as phenytoin and phenobarbital, as well as rifampicin, reduce the absorption of the drug AquadetrimVitamin d3.

Concomitant use of AquadetrimVitamin d3with thiazides increases the risk of hypercalcemia.

Concomitant use with cardiac glycosides may increase their toxic effect (increases the risk of cardiac arrhythmias).

the Simultaneous use of the drug AkvadetrimVitamin D3with antacids containing aluminum or magnesium may provoke toxic effects of aluminium on bones and hypermagnesemia in patients with renal insufficiency.

Ketoconazole may reduce the biosynthesis and catabolism of 1,25 (OH)2-cholecalciferol.

Simultaneous administration of vitamin d3with metabolites or analogues of vitamin d is possible only in exceptional cases and only with the control of serum calcium levels (increases the risk of toxic effects).

Concomitant use with drugs containing high doses of calcium or phosphorus increases the risk of hyperphosphatemia.

Vitamin D may antagonize the drug, prescribed for hypercalcemia, such as calcitonin, etidronate, pamidronate.

Concomitant use of drugs to reduce body weight (orlistat) and lower cholesterol levels can reduce the absorption of vitamin D and other fat-soluble vitamins.

application Features

the drug should be used with caution in immobilized patients, patients taking thiazides, cardiac glycosides, patients with cardiovascular diseases.

During the use of the drug AkvadetrimVitamin D3should consider the additional intake of vitamin D3(co-administration of other preparations containing vitamin D). Combination therapy with vitamin d or calcium should be carried out only under medical supervision and with the control of calcium levels in blood serum and urine.

the Individual provision of a particular need should take into account all possible sources of this vitamin.

Too high dosage AquadermVitamin D3used for a long time, or loading dose can be a cause of chronic hypervitaminosis D3.

determination of a child's daily requirement for vitamin D and how to use it should be established individually and verified every time during periodic studies, especially in the first months of life.

be careful to use the drug to newborns born with a small anterior parietal.

do not take AquadetrimVitamin d3with high doses of calcium at the same time.

During the treatment to control the level of calcium, phosphates and sugars in the blood serum and urine.

caution to use the drug in patients with impaired renal function. Long-term use of the drug requires monitoring of renal function by creatinine level in blood serum.

With caution the drug should be used in pregnant and breastfeeding.

use during pregnancy or lactation.

during pregnancy and lactation, vitamin D should enter the body in the required quantities. It should be monitored with the intake of vitamin D in the body.

Daily doses of up to 500 IU of vitamin D.the Risks of using vitamin D in this dose range are unknown. Avoid prolonged overdose of vitamin D is the possible development

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