URIMAX caps.prolong.actions.TV.0.4 mg 30

URIMAX caps.prolong.actions.TV.0.4 mg 30

Product Code: 12408
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Composition

active ingredients: 1 capsule contains 0.4 mg tamsulosin hydrochloride

Excipients :Polysorbate 80, triacetin, methacrylate copolymer dispersion, sodium lauryl sulfate, microcrystalline cellulose, calcium stearate, capsule gelatin, Indigo (E 132), iron oxide black (E172), iron oxide red (E172), iron oxide yellow (E 172), titanium dioxide (E 171), sodium lauryl sulfate.

The

Dosage form

prolonged action Capsules, solid.

Basic physical and chemical properties: hard gelatin capsules No. 2 with opaque cover of brown-green color and opaque body of orange color, with inscriptions: "CL 23" - on a cover and" 0.4 " - on the case of capsules containing loose spherical granules from white to almost white color.

The

drug description

Means used in urology. ATC code G04C A02. 

The

Pharmacological properties

Pharmacological.

Tamsulosin hydrochloride selectively and competitively blocks postsynaptic ? 1 - adrenoreceptors, in particular ? 1 a and ? 1 D , located in the smooth muscles of the prostate gland, bladder neck and prostatic urethra. This reduces the tone of smooth muscles of the prostate, the neck of the bladder and the prostatic part of the urethra and improves urine. At the same time, symptoms of obstruction and irritation associated with benign prostatic hyperplasia (difficulty in starting urinating, weakening of the urine stream, the presence of residual urination, feeling of incomplete emptying of the bladder, frequent calls for urination, calls for urination at night, urination) decrease .

As a rule, the therapeutic effect develops in 2 weeks after starting this drug. These effects persist for a long time with long-term treatment and largely inhibit the need for surgery or catheterization.

antagonists ? 1-adrenoreceptor have the ability to reduce blood pressure by reducing peripheral vascular tone. During the tests tamsulosin hydrochloride was not clinically marked decrease in blood PRESSURE.

The Pharmacokinetics.

Suction

. Tamsulosin is well absorbed from the digestive tract, and its bioavailability is almost 100%. Suction tamsulosin occurs more slowly after a meal. Uniformity of suction is achieved when the patient

taking tamsulosin hydrochloride at the same time after a meal. Tamsulosin pharmacokinetics has a linear character.

after taking a single dose of tamsulosin hydrochloride after a meal, the peak concentration of tamsulosin in blood plasma is reached after 6: 00, and a stable concentration is formed on the 5th day after daily administration of the drug. The maximum concentration is approximately two-thirds higher than that formed after taking a single dose.

Distribution. In men, tamsulosin binds approximately 99% to plasma proteins. The volume of distribution of the drug is insignificant (about 0.2 l/kg).

Metabolism. Tamsulosin hydrochloride is not amenable to the effect of the first pass and is slowly metabolized in the liver with the formation of pharmacologically active metabolites, maintaining a high selectivity to ? 1-adrenoreceptors. Most of the active substance is present in the blood in unchanged form.

Output. Tamsulosin and its metabolites are excreted mainly in the urine. Approximately 9% of the dose remains in the form of unchanged active substance.

After a single oral dose of tamsulosin hydrochloride after meals and when a stable concentration in the blood plasma half-lives of approximately 10 and 13 hours.

Reading

Treatment of functional disorders of the lower urinary tract in benign prostatic hyperplasia.

Contra

Hypersensitivity to tamsulosin hydrochloride, including drug-induced angioedema or to any of the excipients; a history of orthostatic hypotension; severe hepatic insufficiency.

Special safety precautions

some patients who took tamsulosin, during surgical interventions in case of cataract and glaucoma was noted the atonic pupil syndrome (IFIS, a variant of the syndrome of narrowed pupil), which may cause increase in the number of complications during such an operation. For this reason, patients who are scheduled for surgery to remove cataracts and glaucoma, it is not recommended to appoint tamsulosin.

it is generally recommended to discontinue treatment with tamsulosin 1-2 weeks before surgery for cataract and glaucoma removal. However, the feasibility and timing of discontinuation of treatment tamsulosine today is uncertain.

In preparation for surgery, surgeons ophthalmologists need to know took (or takes) the patient tamsulosin, with a view to preventing the possible complications associated with IFIS.

Tamsulosin hydrochloride should not be administered in combination with strong SURZA4 inhibitors in patients with phenotype, which is characterized by a low level of CYP2D6 metabolism.

Tamsulosin should be used with caution in combination with strong and moderate inhibitors of CYP3A4.

cases of allergic reactions to tamsulosin were Reported in patients with a history of Allergy to sulfonamides. Caution should be exercised when using tamsulosin in patients who have previously been allergic to sulfonamides.

The

Interaction with other medicinal products and other forms of interaction

no drug interaction was observed with atenolol, enalapril, nifedipine or theophylline when tamsulosin was used simultaneously. Concomitant use with cimetidine increases, and with furosemide reduces the concentration of tamsulosin in plasma, but since these levels remain within normal limits, in a special correction of tamsulosin dose is not necessary.

in vitro studies, diazepam, propranolol, trichloromethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not affect the free fraction of tamsulosin in human blood plasma. Likewise, tamsulosin does not change the level of the free fractions of diazepam, propranolol, trichlormethiazide and chlormadinone in human blood plasma.

the Simultaneous application of tamsulosin hydrochloride with strong inhibitors of CYP3A4 may lead to increased effects of tamsulosin hydrochloride. Combined use with ketoconazole (known as a strong CYP3A4 inhibitor ) results in an increase in the maximum concentration (with max) and the area under the concentration-time curve (AUC) to 2.2 and 2.8, respectively.

Simultaneous use of tamsulosin hydrochloride and paroxetine (a strong CYP2D6 inhibitor) results in an increase with max and AUC of 1.3 and 1.6 respectively, but this is not clinically significant.

Tamsulosin hydrochloride should not be administered in combination with strong CYP3A4 inhibitors in patients with low CYP2D6 metabolism.

Tamsulosin hydrochloride should be used with caution in combination with strong and moderate inhibitors of CYP3A4.

concomitant use with other ? 1 adrenergic receptors may enhance hypotensive effect.

application Features

As with other ? 1 -blockers, in some cases, the use of the drug may lower blood pressure, can sometimes lead to loss of consciousness. When the first signs of orthostatic hypotension (dizziness, weakness) appear, the patient should take a horizontal position until the above symptoms disappear.

Before starting treatment with the drug, a medical examination should be performed to identify other comorbidities that may cause symptoms such as benign prostatic hyperplasia. Before starting treatment, it is necessary to conduct a rectal examination of the prostate gland. If necessary, also conduct a test to determine the level of specific prostate antigen (PSA) at the beginning and at the same time intervals during treatment.

Prescribe patients with severe renal failure (creatinine clearance

Tamsulosin hydrochloride should not be administered in combination with strong CYP3A4 inhibitors in patients with low CYP2D6 metabolism.

Tamsulosin hydrochloride should be used with caution in combination with strong and moderate inhibitors of CYP3A4 (see "Interactions with other medicinal products and other forms of interaction").

use during pregnancy or lactation.

the Drug is used in women.

fertility

during clinical trials of tamsulosin, ejaculation disorders were observed for a short and long time. Violations of ejaculation, retrograde ejaculation and lack of ejaculation was noted in poslerastopochnomu period.

Ability to influence the reaction rate when driving motor transport or operating other mechanisms.

study of the effect of the drug on the ability to drive vehicles or machinery was not carried out. However, patients should be warned about the possibility of dizziness, fainting.

Method of application and doses

recommended dose - 1 capsule daily, after Breakfast; the capsule should be swallowed whole, without chewing, as it will prevent the modified release of the active ingredient, drinking milk or water (about 150 ml), standing or sitting.

Children.

the Drug is used for children.

the Safety and efficacy of tamsulosin for children up to 18 years have not been assessed.

Overdose

The Symptoms.

tamsulosin hydrochloride can potentially result in severe hypotensive effects. Severe antihypertensive effect was observed at different degrees of overdose.

Treatment.

in the case of a sharp decrease in blood pressure due to an overdose, maintenance therapy should be carried out to restore the normal function of the cardiovascular system. To normalize blood pressure and heart rate of the patient should be placed in a horizontal position. If this measure does not help, it is recommended to use plasma substitutes and, if necessary, vasoconstrictors. Kidney function should be monitored and maintenance therapy should be carried out. A kidney dialysis is hardly appropriate, because tamsulosin is largely associated with blood plasma proteins.

measures aimed at preventing suction, such as vomiting, will help. With a significant overdose, it is necessary to flush the stomach, as well as take activated charcoal and an osmotic laxative agent, such as sodium sulfate.

Side effects

the part of the nervous system : dizziness, headache, syncope.

From the side of cardiovascular system: palpitations, orthostatic hypotension.

respiratory system: rhinitis, nasal bleeding.

from the digestive tract: constipation, diarrhea, nausea, vomiting, dry mouth.

skin: rash, urticaria, itching, angioedema quince, Stevens-Johnson syndrome.

part of the reproductive system: priapism; ejaculation disorders, including retrograde ejaculation and failure of ejaculation.

by the organ of vision: blurred vision, impaired vision.

in the skin: erythema multiforme, exfoliative dermatitis.

General disorders: asthenia.

Describes cases of intraoperative instability of the iris (narrowed pupil syndrome) during cataract and glaucoma surgery in patients who have been taking tamsulosin for a long time (see section "Special security measures").

during post-registration supervision, cases of intraoperative instability of the iris (narrowed pupil syndrome) during cataract and glaucoma surgery in patients taking tamsulosin are described.

post-Registration experience: in addition to the above adverse reactions, cases of atrial fibrillation, arrhythmia, tachycardia and shortness of breath were reported. Since the world post-registration experience is the source of the above-mentioned spontaneous cases, the frequency of messages and the role of tamsulosin in these cases can not be reliably established.

The

shelf Life

2 years old.

storage Conditions

Store at a temperature not exceeding 30 ° C in its original packaging.

keep out of reach of children.

The

Packaging

10 capsules in blister, 3 blisters in a carton box.

The

Category vacation

According to the recipe.

The

Manufacturer

Macleods PHARMACEUTICALS LIMITED

location of the manufacturer and address of the place of business

the village of Deda, Adhemar, Tehsil Baddi, district Solan, Himachal Pradesh, 174101, India.

TRIBUSTIM 350MG

Tribustim capsules – a drug that acts as a natural stimulant of the male sexual function. 

the Therapeutic effect is due to the influence of the composite composition, which includes extracts:

The
  • Herb Tribulus terrestris.
  • Damiana Leaf.

the Drug is released in capsules of 530 milligrams of the complex active substance in each. The package contains 60 PCs.

the Effect on the body, the testimony

thanks to the multi-faceted effects of the composition of standardized phytoextracts on the body, testosterone production is stimulated. Improves erection and spermatogenesis, increases sexual desire. Also during the reception there is a slight anabolic effect with accelerated formation and renewal of muscle structures.

Applies to:

  • Prevent and reduce sexual dysfunction disorders of involutional and pathological nature.
  • The
  • to Maintain the level of testosterone.
  • The
  • to Enhance spermatogenesis.
  • The
  • to Enhance the sexual activity and potency.
  • The
  • to Improve the stamina and increase muscle mass at high loadings.

the Use and dosage

the Adult males use 1 capsule 2 times/day during meals with some liquid. The duration of therapy can be up to 8 weeks with a repeat of 2-3 times annually.

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