1 g of gel contains 1 mg tyrothricin;
other ingredients:cetylpyridinium chloride, propylene glycol, ethanol 96%, carbomer, trometamol, purified water.The
a Colorless opalescent viscous gel.The
the Engelhard Arzneimittel GmbH & Co. KG
Herzbergstra?e 3, 61138 Niederdorfelden, Germany.
Engelhard Arzneimittel GmbH & amp; co. KG
Herzbergstrasse 3, 61138 Niederdorfelden, Germany.The
Antibiotics for local use.
PBX Code D06A X08.
Tyrothricin is a compound of various cyclic and linear polypeptides showing antibacterial activity and forming as endotoxin by anaerobic, spore-forming Bacillus brevis. This compound contains up to 70-80% Tyrocidin (basic cyclic Decapeptide) and up to 20-30% gramicidin (neutral linear pentadecapeptide).
is mainly Active against gram-positive bacteriaStaph. aureusMSSA,Staph. aureusMRSA,Staph. Haemolyticus, Strep. Pyogenes, Strep. Viridans, Enterococcus faecalis, Diplococcus pneumoniae, Coronebact. spp,Neisseria meningitidessome strains ofNeisseria gonorrhoeae, fungi and Trichomonas, as well as some gram-negative bacteria and many species of fungi, includingCandida.
Tyrothricin has a dose-dependent bacteriostatic or bactericidal action against microorganisms such asClostridia.
the Selection of bacterial cells of substances such as nitrogen and phosphates ensures the effectiveness of tyrocidine. Like a cationic detergent Tyrocidin destroys osmotic bar ? the Prime Minister of the membranes of bacterial cells. Due to the direct effect on the cell wall of the bacterium, the effect of the drug is not limited to inhibition of growth or cell division, it also causes the bactericidal effect of thyrocidin.
in addition, gramicidins form cation channels in the cell membrane of bacteria, which leads to their loss of potassium and, as a result, to changes in intracellular concentrations of cations and cytolysis. Such a component as gramicidin in the future is the disruption of the processes of phosphorylation in the chain of cellular respiration.
Through a special mechanism of action of tyrothricin, not noted in the system of antibiotics, cross-resistance does not occur.
Tirosur Gel accelerates the healing process by cleaning the bottom of the wound and a stimulation of processes of granulation and epithelialization.
it is Unknown to what extent tyrothricin may be absorbed systemically. High concentrations were found in the corneal layer of the skin (after application to the intact surface) and directly in the wound.
topical treatment of superficial wounds with slight exudation wounds and the presence of superinfection, caused by the tyrothricin-sensitive pathogens, such as lacerations, scrapes, abrasions.
hypersensitivity to the components of the drug. Contraindicated for intranasal use; there are reports that this method of application can lead to a violation of smell.
Appropriate action in the application.
care Must be taken when applying to areas around the eyes as this may cause a burning sensation. Tyrosur gel contains polyethylene glycol, which can cause skin irritation.
shelf life after opening of the tube - 3 months.
there are no data on the effect of tyrosur gel during pregnancy. Adequate studies of the effects of tyrothricin and cetylpyridinium chloride on reproductive function in animals have not been conducted. The potential risk for humans is unknown, so it should not be used Tirosur gel during pregnancy.
Unknown, penetrates tyrothricin or cetylpyridinium chloride in breast milk, so you should not use the drug during lactation period.The
has No effect.The
if necessary, tyrosur gel can be used for children of any age.
apply the gel 2-3 times a day in a thin layer on the affected areas of the skin. For small wounds and inflammations of the skin exposed areas of the body to close them are not usually necessary. In case of large damage or wet wounds, protective bandage is recommended, which should be changed in 1-2 days.
the Duration of treatment is determined individually, depending on the course of the disease. If the improvement after a week of the drug is not observed, it is necessary to reconsider the tactics of treatment.
the cases of drug overdose were reported.
skin Irritation, burning, allergic reactions including erythema, urticaria, contact dermatitis.The
do not use after the expiry date indicated on the package.
Store at a temperature not exceeding 25 ° C out of reach of children.The
5 g, 25 g gel in a tube; 1 tube in a cardboard box.The
over the counter.
the Preparation is produced in the form of a viscous homogeneous gel with no color, slightly opalescent. It does not have a pronounced odor. Refers to broad-spectrum antibiotics, is active against most gram-positive bacteria, fungi, as well as some types of gram-negative microorganisms. Supplied in tubes of 5 g, intended for local external use.
the gel consists of thyrotricine (the main component), as well as 96% ethanol, purified water, carbomer, propylene glycol, trometamol (auxiliary components). This composition of the drug provides easy uniform application, good absorbency.
Used in medical institutions, can be used in everyday life in the treatment of the following conditions:
Abrasions on the skin surface. The
the Gel is applied in a thin layer to the damaged skin, after which the treated area is closed with a bandage or left open. Frequency of application, the duration of treatment is prescribed by the doctor.