Spironolactone Darnitsa tablets 50mg №30

Spironolactone Darnitsa tablets 50mg №30

Product Code: 10717
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Composition

active substance:spironolactone;

1 tablet contains spironolactone 25 mg

excipients:potato starch, lactose, povidone, calcium stearate.

The

Dosage form

Pills.

Basic physical and chemical properties:valium pill shape with facet, white or white with a cream shade.

The

drug description

potassium-Sparing diuretics. Antagonists of aldosterone. Code ATX С03D A01.

The

Pharmacological properties

Pharmacodynamics.

the Active substance of the drug - spironolactone - a competitive antagonist aldosterone, affects the distal renal tubules. Due to the blockade of aldosterone suppresses the delay of water and ions Na+ and promotes retention of K+, which not only increases the excretion of Na+and Cl-, and reduces the excretion of K+in the urine, but also decreases the excretion of H+. As a result, the diuretic effect also has a hypotensive effect.

Pharmacokinetics.

after oral administration, the drug is rapidly and completely absorbed into the digestive tract. Bioavailability is 92-99%, and it increases when taken with food.

the Maximum concentration of spironolactone in serum is achieved in 2.6 hours and is 80 ng/ml. Linking blood plasma is about 90%. The half-life period is 1.3 hours.

Spironolactone is metabolized in the liver. Its active metabolites are 7?-dimethyltitanocene and kanrenon. Antialdosterone action determines the canrenone, which is approximately 50% of all metabolites of spironolactone. Indicators of the maximum concentration in plasma and time to achieve it: for 7?-dimethyltitanocene - 391 ng/ml at 3.2 hours for canrenone - 181 ng/ml, 4.3 hours. The half-life of 13.8 hours and 16.5 hours vidpovidno. Spironolactone and its metabolites penetrate the placenta and breast milk.

is Excreted from the body as metabolites mainly by renal excretion, a small part is excreted with feces. Spironolactone has a cumulative effect.

Reading

The
    The
  • Primary aldosteronism.
  • Congestive heart failure in case of inefficiency or intolerance of other diuretics or if it is necessary to increase their effectiveness.
  • Essential hypertension, primarily with hypokalemia, usually in combination with other antihypertensive agents. The

  • cirrhosis of the liver accompanied by edema and/or ascites.
  • The
  • Swelling caused by nephrotic syndrome.
  • Hypokalemia - in case of impossibility of application of other therapy.
  • The
  • Prevention of hypokalemia for patients receiving cardiac glycosides, in the case when other treatments are considered as inappropriate or unsuitable.

Contra

The

    Hypersensitivity to the active substance or other components of the drug. The

  • Acute renal failure, severe violation of azotovydelitelnoy renal function (glomerular filtration rate
  • The
  • Hyperkalemia, hyponatremia.
  • The
  • Addison's Disease.
  • concomitant Use with potassium-sparing diuretics and potassium preparations due to the possibility of hyperkalemia.
The

Interaction with other medicinal products and other forms of interaction

in conjunction with the use of other drugs may:

with antihypertensive agents (especially ganglioblockers, nicardipine, nimodipine)- excessive lowering of blood pressure; while the use should reduce the dose of antihypertensive agents, followed by its correction if necessary;

with ammonium chloride, cholesterol- increased risk of hyperkalemia and hyperchloremic metabolic acidosis

with potassium-sparing diuretics, potassium preparations, ACE inhibitors, angiotensin II receptor blockers, aldosterone receptor blockers, anticholinesterase agents, tacrolimus, cyclosporine- increased risk of hyperkalemia simultaneous use with potassium-sparing diuretics and potassium preparations are contraindicated due to the possibility of hyperkalemia

with other diuretics- enhancing the diuretic effect;

with nonsteroidal anti-inflammatory drugs- increasing the risk of hyperkalemia and renal failure with a concomitant decrease in diuretic, natriuretic and antihypertensive action of spironolactone; while the use of acetylsalicylic acid also suppresses the synthesis of prostaglandins, with antipyrine-increases its metabolism in the liver;

with GCS, ACTH (ACTH) -increased diuretic, natriuretic spironolactone action and paradoxical increased potassium excretion

with ?-and ?-adrenomimetics, carbenoxolone -weakening of spironolactone;

with antipsychotic means, a tricyclic antidepressantincrease the action of spironolactone;

with barbiturates, drugs, ethanol-orthostatic hypotension

with terfenadine-increased risk of ventricular arrhythmia due to hypokalemia and imbalance of other electrolytes;

with carbamazepine -increased risk of hyponatremia;

with digoxin -increased risk of glycoside intoxication due to lengthening of its half-life;

lithium drugsincrease the risk of toxicity because of reduced renal clearance of lithium; it is not necessary to simultaneously apply these drugs;

indirect anticoagulants (coumarin derivatives), mitotane, pressorny amines (epinephrine), cardiac glycosides- weakening of the latter;

with triptorelin, buserelin, gonadorelin -strengthening the action of the latter.

features of the application.

the use of the drug, especially in patients with impaired renal function, can lead to transient increase in the content of urea nitrogen in blood plasma and hyperkalemia, which can lead to the development of cardiac arrhythmias and reverse hyperchloremic metabolic acidosis. The drug should be used with caution in patients with impaired renal function, liver and elderly patients. It is necessary to periodically determine the level of electrolytes in blood plasma and kidney function. In the case of hyperkalemia treatment should be discontinued.

the Drug should be used with caution to patients who have diseases can cause the development of acidosis and/or hyperkalemia.

the Drug should be used with caution in patients with diabetes, especially in the presence of diabetic nephropathy.

spironolactone Therapy can disrupt the process of determining the concentration of cortisol, epinephrine and digoxin (radioimmunological methods).

long-term unjustified use of the drug Should be avoided, since, according to the literature, the prolonged use of spironolactone in animals at maximum doses contributed to the development of carcinoma and myeloid leukemia.

do not drink alcohol while using this medicine.

the Drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

Use in pregnancy and lactation

the Drug is contraindicated during pregnancy and lactation.

Ability to influence the reaction rate when driving motor transport or operating other mechanisms.

during the initial period, the duration of which is individual, it is contraindicated to drive vehicles.

Method of application and doses

the Drug should be administered orally to adults and children. In General, the daily dose is assigned to 1 or 2 doses after meals. The daily dose for 1 reception or the first reception of a preparation at double application is recommended in the morning.

the Duration of treatment is individual, in some cases, can reach several years, it is necessary to use the drug in a minimum effective dose provided continuous monitoring of the electrolyte composition of blood serum and renal function.

For Adults.

Primary hyperaldosteronism.

in preparation for the operation, apply the drug at a dose of 100-400 mg per day.

if surgical treatment is not possible, the drug can be used for a long time as maintenance therapy in the lowest effective dose, determined individually.

in this case, every 14 days the initial dose may be reduced to a minimum effective dose. In long-term treatment, it is recommended to use the drug in combination with other diuretics to reduce side effects.

Congestive heart failure, swelling due to nephrotic syndrome.

the Drug should be used at an initial dose of 100 mg/day in 1 or 2 doses. The daily dose may also range from 25 to 200 mg.

in case of higher doses, the drug can be used in combination with other diuretics acting in more proximal renal tubules. In this case, it is necessary to correct the dose of spironolactone.

Essential arterial hypertension.

the Drug should be used at an initial dose of 50-100 mg per day in 1 or 2 doses in combination with other antihypertensive preparations. Treatment should continue for at least 2 weeks, as by the end of this period the maximum antihypertensive effect is achieved. Further correction of the individual dose, depending on the effect achieved.

cirrhosis of the liver, accompanied by ascites or edema.

if the ratio Na+/K+in urine is more than 1, the drug should be used at an initial dose of 100 mg per day. The maximum daily dose of 100 mg/day. If this ratio is less than 1, the drug is used at a dose of 200 mg per day, with a maximum daily dose - 400 mg/day.

Hypokalemia.

the Drug should be administered at a dose of 25-100 mg per day to patients who lack potassium supplementation or other methods of potassium permissive therapy.

Children.

to use this Preparation in a dose of 1-3 mg/kg of body weight per day in 1 or 2 doses. In the case of maintenance therapy in combination with other diuretics daily dose is 1-2 mg/kg body weight.

if it is necessary to use the drug in children under the age of 3 years, the tablet should be crushed, dissolved and allowed to drink a child in the form of a suspension.

elderly Patients.

the Drug is recommended for use in lower doses, followed by a gradual increase until maximum effect. It should be taken into account that in this category of patients there are hepatic and renal disorders that can affect the metabolism and excretion of the drug.

The

Children

the Drug is used in pediatric practice as directed by a physician.

Overdose

Symptoms:drowsiness/lethargy, confusion, electrolyte disorders.

Treatment:symptomatic therapy. It is necessary to maintain the water-electrolyte and acid-alkaline balances: the appointment of diuretics that remove potassium, parenteral administration of glucose with insulin, in difficult cases - hemodialysis. There is no specific antidote.

Side effects

from the cardiovascular system:arterial hypotension, arrhythmia (in patients with renal insufficiency and those receiving potassium preparations), vasulitis.

from the blood and lymphatic systems:leukopenia (including agranulocytosis), thrombocytopenia, megaloblastic or aplastic anemia, eosinophilia.

from the nervous system and psyche:headache, drowsiness, dizziness, ataxia, paralysis, paraplegia, lethargy, inhibition, confusion.

from the respiratory system, chest and mediastinal organs:change of voice tone.

From the digestive tract:nausea, vomiting, loss of appetite, pain in the abdomen and stomach, diarrhea, constipation, intestinal colic, gastritis, gastric ulcer and duodenal ulcer, stomach bleeding.

from the digestive system:hepatitis, impaired liver function.

from the urinary system:acute renal failure.

from the musculoskeletal system and connective tissue:osteomalacia, muscle spasm, muscle cramps of the lower extremities.

From the metabolism and metabolism:hyperkalemia, hyponatremia, gipercreatininemia, the increase of urea level in blood plasma, hyperuricemia, porphyria, giperhloremiceski metabolic acidosis or alkalosis, dehydration.

on the part of the endocrine system:hirsutism.

on the part of the reproductive system and mammary glands:decreased libido, erectile dysfunction, gynecomastia, menstrual disorders, dysmenorrhea, amenorrhea, metroragia during menopause, swelling and pain of the mammary glands in women, infertility (in the case of high doses - 450 mg per day) , benign tumors of the mammary glands.

from the immune system, skin and subcutaneous tissue:hypersensitivity reactions, including: rash, itching, urticaria, drug fever, hypertrichosis, alopecia, lupus-like syndrome, hyperemia, ring-like erythema, eczema, Stevens-Johnson syndrome.

General:asthenia, increased fatigue.

The

shelf Life

3 years.

storage Conditions

Store in its original packaging at a temperature not exceeding 25 ° C.

keep out of reach of children.

The

Packaging

there are 10 tablets in a contour acheikova packing; 3 contour packing in bundle.

The

Category vacation

According to the recipe.

The

Manufacturer

JSC "Pharmaceutical firm "Darnitsa".

location of the manufacturer and address of the place of business

Ukraine, 02093, G.. Kyiv, Boryspilska str., 13.

PILLS DIACARB 250MG

Diacarb tablets 250 mg №30 are in pharmacology protivoglaucomny and miotic drugs. Means biconvex round shape, white.

Property

the Medicine diuretic and anti-epileptic actions. Inhibits carbonic anhydrase, reduces formation of aqueous humor, due to these effects intraocular pressure is reduced. Antiepileptic activity is associated with decrease in the brain carbonic anhydrase. Distribution:

  • in plasma, the highest concentration is observed after 1-3 hours;
  • reaction with proteins - up to 90%;
  • The
  • half-life equal to 4 to 9 hours;
  • The
  • per day is excreted in the urine 90% of the dose.

Readings

the product is for the treatment of:

  • edema for heart failure and medication;
  • The
  • glaucoma chronic open-angle, secondary, and in the pre-period short-term;
  • epilepsy in children with minor seizures, in adults with large seizures, mixed manifestations of forms.

medical advice is Mandatory as there are contraindications and ambiguous interactions with some drugs.

Application

the medication is Designed for internal ingestion. With edema, the daily rate is prescribed from one tablet. When glaucoma dose is used depending on the intraocular pressure. You can take 1-4 times a day with an open-angle form, on a tablet after 4 hours with a secondary. Also use 4 times a day for one tablet in attacks of closed-angle form of the disease.

In epilepsy the dose depending on the weight of 8-30 mg/kg, the optimum is 1 to 4 tablets.

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