Zolev-500 tablets 500mg №5

Zolev-500 tablets 500mg №5

Product Code: 3969
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Composition active substance: levofloxacin; 1 tablet contains levofloxacin hemihydrate equivalent to levofloxacin 250 mg or 500 mg, or 750 mg Auxiliary substances: microcrystalline cellulose, corn starch, sodium starch (type a), hypromellose, silicon colloidal dioxide, povidone, magnesium stearate, titanium dioxide (E 171), talc, polyethylene glycol 6000, iron oxide red (E172). Dosage form Tablets, film-coated. Pharmacological group Antibacterial agents for systemic use. Fluoroquinolones. ATC code J01M A12. Indications Infections caused by sensitive microorganisms: acute sinusitis; exacerbation of chronic bronchitis; pneumonia complicated and uncomplicated urinary tract infections (including pyelonephritis)); infections of the skin and soft tissues; prostatitis septicemia/bacteriemia; intra-abdominal infection. Contraindications Hypersensitivity to levofloxacin or other quinolones, to the components of the drug, epilepsy, patients with complaints of adverse reactions from tendons after preliminary use of quinolones. Method of application and doses The tablets are taken 1-2 times a day. The dose depends on the type and severity of infection. The duration of treatment depends on the course of the disease and is no more than 14 days. It is recommended to continue treatment for another 48-72 hours after normalization of body temperature or confirmed by microbiological tests of pathogens destruction. Swallow pills with liquid, squeezed enough liquid. Regardless of the meal. The tablet has a distribution line (500 mg and 750 mg) for the convenience of dividing it into parts if necessary. The following recommendations should be followed regarding dosage for adult patients with normal renal function who have creatinine clearance of 50 ml/min: pokazyvaetsya dose, colcheste techniques a day, raspredelitelno treatment, days acute sinusitis500110-14 Exacerbation of chronic бронхита250-50017-10 community-acquired pneumoni500-10001-27-14 Uncomplicated infections of the urinary путей25013 простатит500128 Complicated urinary tract infections (including pyelonephritis)25017-10 Infections of skin and soft тканей500-10001-27-14 Septicemia/bacteriemia500-10001-210-14 Intra-abdominal *50017-14 * In combination with antibiotics with an action on anaerobic causative agents. Dosing for patients with impaired renal function, whose creatinine clearance is less than 50 ml/min: Kreim dosing (depending on the severity of the infection and nosological forms) 50-20 ml/min first dose-250 mg subsequent - 125 mg/24 Chirwa dose of 500 mg subsequent - 250 mg/24 Chirwa dose of 500 mg subsequent-250 mg/12 h 19-10 ml/min first dose-250 mg subsequent - 125 mg/48 Chirwa dose of 500 mg subsequent - 125 mg/24 Chirwa dose of 500 mg subsequent-125 mg/12 h (Including hemodialysis and HAPD *)the first dose - 250 mg subsequent - 125 mg/48 Chirwa dose of 500 mg subsequent - 125 mg/24 Chirwa dose of 500 mg subsequent-125 mg/24 h * After hemodialysis or chronic ambulatory peritoneal dialysis (GAPD) additional doses are not required. Dosing for patients with impaired liver function. Dose correction is not required, since levofloxacin is slightly metabolized in the liver and is excreted mainly through the kidneys. Dosing for elderly patients. If kidney function is not impaired, there is no need for dose adjustment. Adverse reaction Infections and infestations: fungal infections including Candida fungi, proliferation of other resistant microorganisms. From the blood and lymphatic systems: leukopenia, eosinophilia, thrombocytopenia, neutropenia, agranulocytosis, pancytopenia, hemolytic anemia. The immune system: hypersensitivity reactions, including anaphylactic/anaphylactoid shock angioedema (see Section "Peculiarities of use"), anaphylactic and anaphylactoid reactions may sometimes occur even after the first dose. On the part of metabolism and nutrition: anorexia, hypoglycemia, especially in patients with diabetes (see section "Features"), hyperglycemia, hypoglycemic coma. Psychiatric disorders: insomnia, agitation, confusion, nervousness, mental illness (including hallucinations, paranoia), depression, anxiety, restlessness, abnormal dreams, night delirium, psychotic reactions with self-destructive behavior, including suicidal thought or action (see section "Peculiarities of use"). From the nervous system: dizziness, headache, drowsiness, cramps, tremor, paresthesia/hypoesthesia, reduced sense of touch, sensory or sensorimotor peripheral neuropathy, dysgeusia (subjective taste disorder), including ageusia (loss of taste), parosmia (impaired olfaction ), including anosmia (lack of smell), dyskinesia, extrapyramidal disorders, other disorders of coordination of movements during walking, syncope, benign intracranial hypertension. From the organ of vision: visual impairment, blurred vision, temporary loss of vision. On the part of hearing and labyrinth: vertigo, tinnitus, hearing loss, hearing loss. From the heart: tachycardia, palpitations, ventricular tachycardia, which can lead to cardiac arrest; ventricular arrhythmias and arrhythmias such as torsade de pointes (mainly in patients with risk factors for prolongation of THE Qt interval); lengthening of the QT interval on the ECG (see "Features of application" (prolongation of the QT interval) and "Overdose"section). Vascular side: arterial hypotension, allergic vasculitis/leukocytoclastic vasculitis. Respiratory December and mediastinal disorders: shortness of breath, bronchospasm, allergic pneumonitis. From the gastrointestinal tract: lack of appetite, stomatitis; diarrhea nausea vomiting abdominal pain dyspepsia flatulence constipation diarrhoea haemorrhagic, in very rare cases may be indicative of enterocolitis, including pseudomembranous colitis, pancreatitis. Hepatobiliary system: increased activity of liver enzymes (ALT/AST, alkaline phosphatase, GGT) blood bilirubin hepatitis jaundice and severe liver injury, including cases of acute liver failure, primarily in patients with severe underlying diseases (see section "Peculiarities of use"). The skin and subcutaneous tissue: rash, itching, hives, increased sensitivity to sun and ultraviolet radiation, toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, exudative erythema multiforme, hyperhidrosis, photosensitivity. Sometimes there may be skin-mucous reactions even after taking the first dose. From the musculoskeletal system and connective tissue: tendon lesions (see section "Peculiarities of application"), including their inflammation (tendinitis) (for example, Achilles tendon), arthralgia, myalgia, rupture of tendons, ligaments, muscles, arthritis. Possible muscle weakness , which may be of particular importance for patients with severe myasthenia gravis, rhabdomyolysis. The kidneys and urinary system: increased creatinine in the serum, acute renal failure (e.g. due to interstitial nephritis). General disorders and conditions at the site of administration: asthenia, General weakness, fever, pain (including back pain, chest and limbs), attacks of porphyria in patients with porphyria. Overdose Symptoms: dizziness, unconsciousness, seizures, nausea and erosion of the mucous membranes, prolongation of the interval-QT or increased manifestations of other adverse reactions. In cases of overdose, it is necessary to carefully monitor the patient, including ECG. Treatment is symptomatic. Hemodialysis, including peritoneal dialysis or CAPD, is non-effective for levofloxacin excretion from the body. There are no specific antidotes. Application during pregnancy and lactation Due to the lack of research and possible damage to the articular cartilage by quinolones in the body that grows, the drug should not be prescribed during pregnancy and lactation. If pregnancy occurs during treatment, the doctor should be informed. Children Children are contraindicated to use the drug, because it is possible to damage the articular cartilage. Application features With a very severe course of pneumonia caused by pneumococci, levofloxacin may not give an optimal therapeutic effect. Hospital

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