Ospamox AMOXICILLINUM tablets 1000mg №12

Ospamox AMOXICILLINUM tablets 1000mg №12

Product Code: 4070
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Composition

active substance:amoxicillin;

1 tablet contains amoxicillin 500 mg or 1000 mg in the form of amoxicillin trihydrate;

Excipients:magnesium stearate, povidone( K 25), starch sodium (type A), microcrystalline cellulose

shell: titanium dioxide (E 171), talc, hypromellose.

The

Dosage form

Tablet, film-coated.

basic physico-chemical properties:oval, biconvex tablets from white to cream color with a characteristic odor, with a notch on both sides.

The

drug description

Antimicrobial agents for systemic use. Beta-lactam antibiotics. Wide-spectrum penicillins. Amoxicillin. ATC code J01C A04.

The

Pharmacological properties

Pharmacodynamics.

Amoxicillin is a semisynthetic aminopenicillin a broad-spectrum antibiotic for oral administration. Suppresses the synthesis of bacterial cell wall. It has a wide range of antimicrobial action.

sensitive To the drug, these types of micro-organisms:

The
  • gram-positive airbagsEnterococcus faecalis, Listeria monocytogenes, Streptococcus agalactiae, Streptococcus bovis, Streptococcus pyogenes;
  • The
  • gram-negative aerobesHelicobacter pylori;
  • anaerobes:Peptostreptococci;
  • The
  • other:Borrelia.

sensitive non-permanent (acquired resistance may be a problem):Enterococcus faecium, Streptococcus pneumoniae, Streptococcus viridans, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Proteus mirabilis, Prevotella, Fusobacterium spp.

Stable species such asStaphylococcus aureus, Acinetobacter,Citrobacter,Enterobacter,Klebsiella,Legionella, Morganella morganii, Proteus vulgaris, Providencia, Pseudomonas, serrata, Bacteroides fragilis, Chlamydia, Mycoplasma, Rickettsia.

Pharmacokinetics.

Suction

.the Absolute bioavailability of amoxicillin is dose dependent and ranges from 75 to 90%. In doses of 250 mg to 1000 mg bioavailability (parameters AUC and Cmax) is linearly proportional to the dose. At higher doses, the degree of absorption decreases. Eating practically does not affect the absorption of the drug. After taking a single dose of 500 mg of amoxicillin concentration in plasma is 6 to 11 mg/L. the Maximum concentration in the blood plasma is reached after 1-2 hours. 

Distribution.Approximately 17% of amoxicillin is bound with blood plasma proteins. Therapeutic concentration is rapidly achieved in blood serum, lungs, bronchial secretion, fluid of the middle ear, bile and urine. The concentration of the drug in the bile exceeds its concentration in the blood 2-4 times. Amoxicillin poorly penetrates the cerebrospinal fluid; however, with inflammation of the meningitis (eg, meningitis) concentration in cerebrospinal fluid is about 20% of the concentration in blood plasma.

Metabolism.Amoxicillin is partially metabolized, most of its metabolites are inactive.

Output.Amoxicillin is excreted mainly by the kidneys. Approximately 60-80% of the dose eliminates through 6:00 unchanged. The half-life of the drug is 1-1.5 hours. In violation of kidney function, the half-life of the drug increases and reaches 8.5 hours in anuria.

the half-life of the drug does not change in violation of liver function.

Reading

Caused by sensitive to the drug microorganisms infection:

The
  • respiratory tract
  • The
  • of the urogenital system;
  • The
  • of the digestive tract (including the eradication ofHelicobacter pyloriin patients with an ulcer

stomach or duodenum, as part of combination therapy);

The
    The
  • of the skin and soft tissues.

when using the drug in combination therapy for eradicationHelicobacter pylorishould take into account information about other drugs used in combination therapy.

Contra

Hypersensitivity to amoxicillin, other penicillins or to excipients of the drug. A history of severe hypersensitivity reactions (including Anaphylaxis) to beta-lactam antibiotics (including Cephalosporins, carbapenems or monobactams).

The

Interaction with other medicinal products and other forms of interaction

Probenecid.concomitant use with amoxicillin is not recommended. Probenecid reduces renal tubular secretion of amoxicillin, which can lead to an increase in its level in blood plasma and prolongation of action.

Allopurinol.Concurrent use with amoxicillin contributes to allergic skin reactions.

Tetracycline.Tetracycline and other drugs having bacteriostatic effect(antibiotics of tetracycline series, macrolides, chloramphenicol)can neutralize bactericidal effect of amoxicillin.

Concomitant use ofaminoglycosidesis possible (synergistic effect).

Oral anticoagulants.when penicillin antibiotics and anticoagulants were used, there were no reports of their interaction. However, there are some cases of increasing the level of international normalized ratio (INR) in patients who simultaneously took amoxicillin and acenocumarol or warfarin. If such use is necessary, prothrombin time or INR should be carefully monitored with the addition or discontinuation of amoxicillin treatment. In addition, it may be necessary to correct the dose of oral anticoagulants.

Methotrexate.the use of amoxicillin with methotrexate leads to an increase in the toxic effect of the latter. Amoxicillin reduces renal clearance of methotrexate, so you should check the level of its concentration in the blood serum.

Mechanisms.

Elevated levels of the drug in blood plasma and urine can affect the results of certain laboratory tests. When applying chemical methods, false positive results are usually observed.

When testing for the presence of glucose in urine it is recommended to use enzymatic glucose oxidase test.

the presence of amoxicillin may affect the results of quantification of estriol in pregnant women.

application Features

Hypersensitivity.before starting treatment with amoxicillin, it is necessary to accurately determine the history of hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam antibacterial drugs and allergens.

Serious and sometimes even lethal cases of hypersensitivity (anaphylactoid reactions) are observed in patients during penicillin therapy. Such reactions are more likely to occur in patients with a history of hypersensitivity to penicillins or hypersensitivity to various allergens. In case of an allergic reaction, amoxicillin therapy should be discontinued and appropriate treatment prescribed.

microorganisms are Insensitive. Since amoxicillin is not intended for the treatment of certain types of infections, the drug should be used only when the pathogen is identified, or when there is reason to believe that the infectious agent is likely to be sensitive to the action of amoxicillin (see Section "Pharmacological properties") . This is especially true for patients who are treated for urogenital infections and severe ENT infections.

Convulsions.in patients with impaired renal function, as well as in those who take high doses of the drug, has a predisposition (for example, the presence of a history of epileptic seizures, treated epilepsy, meningitis (see Section "Adverse reactions") may experience seizures.

Renal failure.in patients with renal insufficiency, the dose of amoxicillin should be adjusted depending on the degree of renal insufficiency.

Skin reactions.The onset

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