1 tablet contains 50 mg furagin
other ingredients:lactose monohydrate, sugar, potato starch; stearic acid Polysorbate.The
Basic physical and chemical properties:ploskotsilindricheskie tablets with beveled edges from yellow to yellow with an orange tint.The
Antimicrobial agents for systemic use. Nitrofuran derivatives. Furazidin.
Code ATC J01X E03.The
furagin-nitrofuran antibacterial agent with bacteriostatic action. Effective against gram-positive (Staphyloccocus epidermidis,Staphyloccocus aureus,Staphyloccocus faecalis),gram-negative ((Enterobacteriaceae, Klebsiella spp, Eschrichia coli) bacteria. High bacteriostatic activity furagin associated with the presence of aromatic nitro group. Resistance to furagin develops slowly. Furagin suppresses the enzyme systems of microorganisms, as well as other biochemical processes in the bacterial cell, in turn, to disrupt the cytoplasmic membrane and the bacterial cell membrane.
Absorption.Furagin is well absorbed from the digestive tract. The absorption of the drug takes place mainly at the distal part of the small intestine by passive diffusion (higher than the absorption from the proximal section several times). After a single dose of 200 mg, the maximum concentration of furagin is achieved in the blood plasma after 30 minutes, stored at this level for 1:00, then slowly decreases. Bacteriostatic concentration of furagin in blood plasma is maintained for 8-12 hours. Furagin is associated with blood plasma proteins.
Metabolism/elimination. 10% of the dose is metabolized in the liver and kidneys. In violation of kidney function occurs biotransformation of most of the dose.
half-life of furagin is short (around 1:00). Furagin is excreted by the kidneys, primarily by tubular secretion (85%). 8-13% furagin get into the urine in an unmodified form, where its concentration is on average much higher than the minimal concentration for most sensitive bacteria. The maximum concentration of furagin in urine-5.7 mg/ml.
Furagin penetrates well through the placental barrier.
Acute and chronic urinary tract infections: pyelonephritis, cystitis, urethritis; prostatitis postoperative infections of the genitourinary system.
hypersensitivity to furagin, to nitrofuran group derivatives or to auxiliary substances of the drugThe
Tools, alkalizing the urine, reduce the therapeutic effect Furagin (Furagin accelerate excretion with urine).
products that acidify urine (acids, including ascorbic acid, and calcium chloride), increase the concentration of Furagin in urine (slowing its excretion in urine) and thus increases the therapeutic effect of the drug, but increases the risk of increased toxicity.
Use simultaneously with chloramphenicol, ristomycin and sulfonamides increases the oppression.
through the antagonism of Furagin with quinolones (nalidixic acid, oxolic acid, norfloxacin) should be avoided simultaneous use of these drugs.
the use of probenecide and sulfinpyrazone reduces the excretion of furagin, which increases the risk of adverse events and toxicity.
the Simultaneous use of Furagin and antacids (which contain magnesium trisilikat) reduces the absorption Furagin.
in renal insufficiency It is not recommended to use furagin with aminoglycosides simultaneously.
Antibacterial action Furagina greatly enhanced with the simultaneous use of antibiotics (penicillins and cephalosporins), well combined with tetracycline and erythromycin.
During treatment can not drink alcohol, because alcohol may increase the severity of side effects (tachycardia, pain in the heart area, headache, nausea, vomiting, convulsions, decreased blood pressure, fever, anxiety).
the drug Should be used with caution in the following cases:The
Application Furagin is not recommended for urosepsis and infection of the renal parenchyma.
In the course of experimental studies and clinical observations of patients revealed that nitrofurans adversely affect the function of testes, manifested in the form of reducing the number of sperm and the ejaculate, reducing the mobility of Spermatozoid and pathological changes of their morphology.
When using Furagin may experience diarrhea due to suppression by the drug of the normal microflora of the large intestine.
in rare cases, it is possible to develop pseudomembranous colitis, the cause of which is the suppression of the natural microflora of the rectum and the reproduction of Clostridium difficult. With a slight form of pseudomembranous colitis, it is enough to stop taking the drug. When carrying out appropriate therapy, do not take drugs that slow down intestinal peristalsis. Taking the drug with food reduces the risk of colitis, without significantly affecting the absorption of the drug.
a Laboratory study of patients receiving Furagin may give a false positive reaction to the presence of glucose in the urine, if the method of recovery of copper is used to determine. The results of the determination of glucose in the urine, performed by the enzyme method, Furagin does not affect.
In the case of long-term therapy should be monitored blood test (white blood cell count), functional parameters of the liver and kidneys, as well as to monitor lung function, especially in patients aged 65 years.
the preparation contains sugar, which should be taken into account in patients with diabetes mellitus.
For prevention of neuritis at the same time it is advisable to take antihistamines and b-complex vitamins (nicotinamide, thiamine).
the Drug is contraindicated during pregnancy and lactation.The
Usually the drug does not affect the reaction rate when driving motor transport or operating other mechanisms, but individuals who have during treatment occur dizziness, drowsiness or other side effects from the Central nervous system, caution must be exercised.
the Drug is taken orally, immediately after meals, drinking plenty of water.
Adult100-200 mg (2-4 tablets) 2-3 times a day. The course of treatment is 7-10 days depending on the sev