active substance: furazidin (furagin)
1 tablet contains 50 mg furagin;
excipients: corn starch, sucrose, silicon colloidal dioxide, stearic acid.
Basic physical and chemical properties: tablets, not coated, flat on both sides, yellow - orange color, with a dividing line on one side, chamfered.
Antimicrobial agents for systemic use.
ATX Code J01X E03
Furagin, that is, furazidin (nitropyrimidin - americanto) is a product of nitrofuran. The preparations of this group act bacteriostatically on a wide range of microorganisms, including gram-positive bacteria ( Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus faecalis ) and many gram-negative strains ( Enterobacteriaceae: Salmonella, Shigella, Proteus, Klebsiella, Escherichia, Enterobacter ). Nitrofuran derivatives of have Antiprotozoal action and is only slightly active against fungi. Do not affect the Pseudomonas aeruginosa ( Pseudomonas aeruginosa ) and most strains of the regular Proteus sticks ( Proteus vulgaris ).
Stronger action furagin is in an acidic medium (pH 5.5), alkaline medium weakens its action. The strong bacteriostatic action furagin associated with the presence of aromatic Deputy, with the nitro group.
nitrofuran Derivatives are reduced to active derivatives via bacterial flavoproteins. Further, these derivatives transform ribosomal proteins and other compounds necessary for the synthesis of cellular proteins, nucleic acids (DNA and RNA) and in the processes of cellular respiration. Cross resistance to nitrofuran derivatives in combination with antibiotics and sulfanilamides was not observed.
after oral administration, furagin is absorbed very quickly and reaches a maximum serum concentration for about 0.5 hours. The curve of concentration in serum indicates the open, oncompetent model of the distribution of the drug. These concentrations are insignificant from a therapeutic point of view and are about 4.2 microns/ml.
the Conclusion in people taking furagin, which is determined in the study of its relative bioavailability, was an average of about 6.25 mg/ml.according to the information available in the literature, it follows that taking nitrofuran derivatives with food, especially protein - rich, increases bioavailability by 40-50% and increases excretion in the urine, that is, increases the concentration of the drug in the urine, affects
a urinary tract Infection.
Hypersensitivity to nitrofuran derivatives or to any of the excipients.
Pregnancy and lactation period.
Renal failure (creatinine clearance below 60 ml/min or increased serum creatinine concentration). Contraindicated for patients on hemodialysis or peritoneal dialysis.
polyneuropathy (including diabetic).
glucose - 6 - phosphate dehydrogenase Deficiency (risk of hemolysis).
Porphyria. Severe hepatic insufficiency.The
Furagin is an antagonist of nalidixic acid, weakens its bacteriological effect. Antibiotics-aminoglycosides and tetracycline, taken in combination with furagin, enhance its antibacterial effect. Chloramphenicol and ristomycin increase hemo - toxic effect furagin.
Uricosuric drugs, such as probenecid (high doses) and sulfinpirazon, reduce the excretion of nitrofuran derivatives by tubules and can cause cumulation of furagin in the body, increasing its toxicity and reducing urine concentrations below the minimum bacteriostatic level, which leads to a weakening of therapeutic efficacy.
with the simultaneous use of drugs with alkaline medium containing magnesium trisilicate, the absorption of furagin decreases.
Atropine slows down the absorption of nitrofuran derivatives, but the total amount of the absorbed substance does not change. Simultaneous intake of b vitamins increases the absorption of nitrofuran derivatives.
In the period of application of derivative nitrofuran observed false positive test results that determine the amount of glucose in the urine using the solutions Benedict's and Fehling's. The use of enzymatic methods for determining glucose in urine gave the correct results.The
Special care should be taken to patients with impaired renal function and liver, neurological disorders, anemia, electrolyte disorders, deficiency of b vitamins and folic acid, as well as lung disease.
caution needs to accept the diabetes as furagin can cause rozvitok polyneuropathy. Patients, taking nitrofuran derivatives, observed the development of peripheral neuropathy, which in severe cases may be irreversible and life-threatening patient. Therefore, when the first symptoms of neuropathy (paresthesia) admission Europeregio should be discontinued.
in patients taking derivatives nitrofurane, observed acute, subacute and chronic reactions from the lungs. In the presence of such symptoms, the drug should be stopped immediately.
long-term use of the drug requires monitoring of blood morphology (leukocytosis) and biochemical parameters of kidney and liver functions.
the Medicine contains sucrose. Do not use in patients with rare hereditary disorders associated with fructose intolerance, malabsorption of glucose - galactose, sucrose - isomaltase deficiency.
Use in pregnancy or breast-feeding.
due to the lack of clinical data on the possible teratogenic effect of furagin, the drug is contraindicated during pregnancy and childbirth due to the risk of hemolytic anemia in the newborn.
Ability to influence the reaction rate when driving motor transport or operating other mechanisms.
no data are available on the effect of furagin on the ability to drive and maintain vehicles. However, some patients may have side effects that can affect the speed of psychomotor reactions (see "Side effects. From the nervous system").
100 mg (2 tablets) 3 times a day.
Mode of application.
the medicine of Euroforgen taken orally during a meal rich in proteins that increase the bioavailability of derivative nitrofuran.
the Drug is taken from 5 to 10 days. If necessary, the course of treatment can be repeated in 10-15 days.
the Medicine should not be used in children.The
since the drug is excreted from the body by the kidneys, patients with impaired renal function have an increased risk of overdose. When overdosing, the following symptoms are possible: headache, dizziness, allergic reactions, nausea, vomiting, anemia, ataxia, tremor, symptoms of a neurotoxic nature.
in case of overdose, gastric lavage and infusion solutions are recommended. Blood morphology check, laboratory analysis of liver function and monitoring of lung function are shown. In severe cases, hemodialysis should be carried out.
for the prevention of neuritis-b vitamins
the most common adverse reactions are nausea (8%), headache (6%) and excessive flatulence (1.5%). Other symptoms were observed by no more than 1% of patients. Side effects classified according to the organ systems listed below.
the blood and lymphatic system:
Cyanosis as a result of methemohlobinemia. Patients with a deficit glukozo - 6 - fosfatdegidrogenaza application furagin may result in megaloblastic or hemolytic anemia.
From the nervous system:
Dizziness, drowsiness, blurred vision, peripheral neuropathy, including acute or irreversible (its formation contribute to the particular renal insufficiency, anemia, diabetes, electrolyte disorders, vitamin a deficiency).
from the respiratory system, chest and mediastinum:
Acute, subacute and chronic hypersensitivity reactions to a derivative of nitrofuran. Chronic reactions were observed in patients taking furagin for more than 6 months. Chronic reactions of the lungs (including pulmonary fibrosis and interstitial pneumonia disseminated) are possible, especially in older patients. Acute hypersensitivity reactions from the respiratory system: fever, chills, cough, chest pain, shortness of breath, exudate in the pleural cavity, changes in the radiological picture of the lungs and eosinophilia. Most often, these side effects quickly disappeared after discontinuation of the drug.
in the case of chronic reactions, the increase in symptoms and their turnover after discontinuation of the drug depend on the continuation of treatment after the appearance of the first undesirable symptoms.
from the digestive system:
Constipation, diarrhea, dyspepsia, abdominal pain, vomiting, sialoadenitis, pancreatitis, pseudomembranous colitis.
the part of the skin and subcutaneous system:
Alopecia, exfoliative dermatitis, polymorphic erythema, Stevens syndrome - Johnson's.
Fever, chills, poor health, infections by microorganisms resistant to nitrofuran derivatives, most often by sticks from the Pseudomonas family or by fungi from the Candida family .
from the immune system:
Itching, urticaria, anaphylaxis, Quincke's edema, rash.
from the liver and biliary tract:
Symptoms of drug-induced hepatitis, cholestatic jaundice, liver parenchyma necrosis.
Clinical studies have shown that nitrofuran derivatives have a negative effect on testicular function, can cause a decrease in sperm mobility, reduce sperm production, and lead to pathological changes in sperm morphology.
Store in a dry place in its original packaging.The
30 tablets in blister from PVC and aluminium foil in a cardboard box.The
According to the recipe.The
Pabianice pharmaceutical plant Polfa A. T., Poland.The
Marsh street. John. Pi?sudskiego 5, 95-200, Pabianice, Poland.
Urorec is a member of the group of alpha adrenoreceptor antagonists containing the active substance silodosin. The drug is released in the form of solid capsules of gelatin, with a content of 4 milligrams of silodosin in each. In a package of 3 blisters, each 10 capsules.
Silodosin acts as a substance with a high selective effect. It is the antagonist of alpha1-adrenoreceptors located in the prostate, the bladder (at the bottom and in the neck), as well as in the prostate region of the urethra. Due to the blockade of these recipes there is a relaxation of smooth tissues of these departments, so the outflow of urine becomes better. During the administration of the drug eliminates irritation and obstruction caused by BPH.
the Drug is indicated for the symptomatic treatment of BPH.
Uretek consumed orally. The normal daily dose is two capsules 1 time/day with a possible decrease in dosage if necessary.
the Drug is taken during a meal. Swallow the capsule whole with some liquid. During therapy, it is recommended to observe the regimen of administration, namely the same time of use.